英文别名 (2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate
分子式 C16H26NO4SC7H7O3S;C23H
物理化学性质 熔点84-87°C 分子结构图
方法 以环氧氯丙烷为起始原料经过醚化和环合“一锅法”、再醚化、催化氢化、酰化、成盐5步反应合成了甲磺司特,纯度大于99%，总收率37.2%
【关键词】 甲磺司特 环氧氯丙烷 支气管哮喘
Abstract:Objective To optimize the synthetic route of suplatast tosilate to make it suitable for industrial production. Methods Epichlorohydrin was used as starting material and adopted hydrocarbylation and cyclization by oneot method,followed with reydrocarbylation,catalytic hydrogenation,acylation,and salt formation to afford suplatast tosilate. Results The target compound was synthesized,with its purity more than 99 % and the total yield of 37.2 %. The structure of the product was elucidated by MS,1HMR,IR and elemental analysis. Conclusion Compared with the synthesis route that had been reported in the literature,the synthesis route in this study was optimized by exploration of optimization of the Molar ratio of raw materials,shortening of the reaction time,and simplification of synthesis route.
Key words:suplatast tosilate; epichlorohydrin; bronchial asthma
甲磺司特(1，suplatast tosilate,ST)，化学名：(±)(2(4(3惨已趸2掺腔丙氧基)苯基氨基甲酰)乙基)二甲基锍对甲苯磺酸盐[1]